Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 19 0.003 0.373 0.16 0.096
biological_process el 19 0.583 0.912 0.767 0.104
biological_process ka 19 0.001 0.367 0.145 0.096
biological_process rf 19 0.003 0.373 0.16 0.096
cellular_component ct 19 0.001 0.557 0.176 0.148
cellular_component el 19 0.08 0.924 0.457 0.231
cellular_component ka 19 0.001 0.554 0.172 0.148
cellular_component rf 19 0.001 0.557 0.176 0.148
disease ct 9 0.034 0.676 0.345 0.236
disease el 9 0.089 0.899 0.464 0.271
disease ka 9 0.004 0.646 0.339 0.238
disease rf 9 0.034 0.676 0.344 0.236
genetic_interaction ct 17 0.0 0.975 0.544 0.31
genetic_interaction el 17 0.0 0.976 0.557 0.306
genetic_interaction ka 17 0.0 1.0 0.882 0.322
genetic_interaction rf 17 0.0 0.965 0.545 0.307
molecular_function ct 19 0.003 0.829 0.322 0.269
molecular_function el 19 0.007 0.955 0.367 0.257
molecular_function ka 19 0.002 0.831 0.33 0.266
molecular_function rf 19 0.004 0.829 0.322 0.269
pathway ct 19 0.001 0.909 0.505 0.312
pathway el 19 0.001 0.711 0.369 0.263
pathway ka 19 0.001 1.0 0.843 0.363
pathway rf 19 0.001 0.704 0.347 0.24
phenotype ct 9 0.006 0.644 0.434 0.238
phenotype el 9 0.077 0.58 0.313 0.198
phenotype ka 9 0.005 0.688 0.46 0.258
phenotype rf 9 0.006 0.644 0.434 0.238
protein_interaction ct 19 0.002 0.4 0.16 0.11
protein_interaction el 19 0.003 0.258 0.091 0.07
protein_interaction ka 19 0.008 1.0 0.74 0.435
protein_interaction rf 19 0.002 0.386 0.149 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 19 0.0 0.806 0.377 0.259
integration_mean_by_presence el 19 0.204 0.708 0.449 0.142
integration_mean_by_presence ka 19 0.001 0.82 0.335 0.232
integration_mean_by_presence rf 19 0.0 0.841 0.308 0.26
mean ct 19 0.0 0.748 0.284 0.254
mean el 19 0.0 0.504 0.155 0.136
mean ka 19 0.0 0.329 0.125 0.111
mean rf 19 0.0 0.411 0.15 0.133

CDF plots of non integrated kernels

CDF plots of integrated kernels