Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net	Kernel	Elements	Min	Max	Average	Standard_Deviation
biological_process	ct	19	0.003	0.373	0.16	0.096
biological_process	el	19	0.583	0.912	0.767	0.104
biological_process	ka	19	0.001	0.367	0.145	0.096
biological_process	rf	19	0.003	0.373	0.16	0.096
cellular_component	ct	19	0.001	0.557	0.176	0.148
cellular_component	el	19	0.08	0.924	0.457	0.231
cellular_component	ka	19	0.001	0.554	0.172	0.148
cellular_component	rf	19	0.001	0.557	0.176	0.148
disease	ct	9	0.034	0.676	0.345	0.236
disease	el	9	0.089	0.899	0.464	0.271
disease	ka	9	0.004	0.646	0.339	0.238
disease	rf	9	0.034	0.676	0.344	0.236
genetic_interaction	ct	17	0.0	0.975	0.544	0.31
genetic_interaction	el	17	0.0	0.976	0.557	0.306
genetic_interaction	ka	17	0.0	1.0	0.882	0.322
genetic_interaction	rf	17	0.0	0.965	0.545	0.307
molecular_function	ct	19	0.003	0.829	0.322	0.269
molecular_function	el	19	0.007	0.955	0.367	0.257
molecular_function	ka	19	0.002	0.831	0.33	0.266
molecular_function	rf	19	0.004	0.829	0.322	0.269
pathway	ct	19	0.001	0.909	0.505	0.312
pathway	el	19	0.001	0.711	0.369	0.263
pathway	ka	19	0.001	1.0	0.843	0.363
pathway	rf	19	0.001	0.704	0.347	0.24
phenotype	ct	9	0.006	0.644	0.434	0.238
phenotype	el	9	0.077	0.58	0.313	0.198
phenotype	ka	9	0.005	0.688	0.46	0.258
phenotype	rf	9	0.006	0.644	0.434	0.238
protein_interaction	ct	19	0.002	0.4	0.16	0.11
protein_interaction	el	19	0.003	0.258	0.091	0.07
protein_interaction	ka	19	0.008	1.0	0.74	0.435
protein_interaction	rf	19	0.002	0.386	0.149	0.104

Table 2. Backup position values for every kernel after integration

Integration	Kernel	Elements	Min	Max	Average	Standard_Deviation
integration_mean_by_presence	ct	19	0.0	0.806	0.377	0.259
integration_mean_by_presence	el	19	0.204	0.708	0.449	0.142
integration_mean_by_presence	ka	19	0.001	0.82	0.335	0.232
integration_mean_by_presence	rf	19	0.0	0.841	0.308	0.26
mean	ct	19	0.0	0.748	0.284	0.254
mean	el	19	0.0	0.504	0.155	0.136
mean	ka	19	0.0	0.329	0.125	0.111
mean	rf	19	0.0	0.411	0.15	0.133

CDF plots of non integrated kernels

CDF plots of integrated kernels